Well, it's March, which means March Madness, and I can't think of anything more maddening than encountering something I can't eat, but I'm pretty sure this would drive me, or make me, mad (maybe both).

Leela: I'm afraid Fry is suffering from ocean madness.
Fry: Every time something good happens to me you say it's some kind of madness, or I'm drunk, or I ate too much candy. Well I saw a real mermaid and I wish for once my friends would have decency and kindness to believe me.
Leela [whispering]: Ocean madness.